Contraception

Medicines that can affect contraception

Learn more about which medicines may interact with specific types of contraception.

It's completely normal to wonder how your contraception might interact with any medication you're taking. Most medicines don't affect contraception, but there are some treatments that can make certain contraceptive methods less effective. This is because certain medicines might affect how hormones are absorbed, processed or broken down by the body.

The contraceptive pill is the method most commonly associated with medicine interactions, although other hormonal contraceptives can sometimes be affected too. If you’re unsure, it’s always best to check with a pharmacist or other healthcare professional – but we’ll cover some of the key facts and myths below.

Last reviewed: October 2026

Next review: October 2029

Reviewed by: Elliott Patrick, Head of NHS Services

Medicines that may affect hormonal contraception

Some medicines are known to interact with hormonal contraception. Examples might include certain:

  • Epilepsy medicines
  • HIV medications
  • Tuberculosis treatments
  • Medicated weight loss treatments
  • St John's Wort (a herbal remedy used to treat moderate depression)
  • Other medicines used for long-term medical conditions

The potential interaction depends on both the medication you're taking, and the type of contraception you're using. Everyone's circumstances are different, so it's best to seek medical advice to be sure.

Taking weight loss medication with the contraceptive pill

If you're taking weight-loss medication and using oral contraception, it's important to be aware that some treatments may affect how well the contraceptive pill works.

Certain treatments like Mounjaro work by slowing down digestion, which can reduce the absorption of oral medicines, such as the contraceptive pill. Even if the weight loss treatment you're using doesn't work in this way, it could still cause side effects such as vomiting or diarrhoea, which may in turn reduce the effectiveness of your oral contraception.

If you're unsure about how your weight loss medication and contraceptive pill might be interacting, you can speak to a pharmacist or healthcare professional for advice.

Taking antibiotics with the contraceptive pill

Most antibiotics don't impact the effectiveness of the contraceptive pill, however, there are a small number of exceptions, and some antibiotics may require additional precautions.

If you're prescribed antibiotics and use hormonal contraception, it's always worth checking with your pharmacist on whether you should be taking any additional contraceptive precautions.

What to do if you start a new medication or supplement while using contraception

Whenever you're prescribed, recommended or planning to buy new medicine or supplements, it's always a good idea to mention if you're using hormonal contraception. Although most herbal products and supplements can be bought without a prescription, you might be surprised to learn that some of them can still affect hormonal contraception. A pharmacist can quickly check for any interactions and advise if:

  • Additional contraception precautions are recommended
  • An alternative medication might be more suitable
  • Emergency contraception advice may be appropriate

This might be particularly relevant if you're exploring contraception after having a baby, or contraception during menopause, where you might be taking other medicines and supplements.

Taking the contraceptive pill when you're ill

If you're unwell while using contraception, then it's not just medicine interactions that you need to think about. If you're sick (vomiting) or experiencing diarrhoea, then your body may not absorb oral contraception properly. This means that your pill might be less effective than usual.

If you find yourself in this situation and aren't sure what to do, then you can speak to a pharmacist or other healthcare professional for advice.

FAQs

What medicines stop the contraceptive pill from working?
Certain medicines, such as some epilepsy, weight loss and HIV treatments can interact with hormonal contraception. You should always check with a healthcare professional for personalised advice.
Can antibiotics affect the contraceptive pill?
Most antibiotics don't affect hormonal contraception, but there are a few exceptions. If you're prescribed antibiotics and you use contraception, it's always worth checking with your pharmacist in case extra precautions need to be taken.
Can antidepressants affect the pill?
In most cases, antidepressants and oral contraception can be taken together safely, but it's always worth mentioning any medicines you're taking when discussing contraception with a pharmacist or healthcare professional.
Can painkillers affect contraception?
For most people, common painkillers such as paracetamol and ibuprofen don't impact the effectiveness of contraception, including the contraceptive pill. This means you can typically still take pain relief for common symptoms like headaches, period pain and muscle aches without worrying about your contraception becoming less effective. However, if you're taking medication regularly or for a long-term condition, it's always worth checking with a healthcare professional in case this does impact your contraception.
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