Learn whether you can take Mounjaro with other medications
When you're approved to take Mounjaro, you will be asked if you take any other medicines. This is because some drugs can interact with one another, potentially causing harmful side effects.
But this does not mean you cannot take Mounjaro if you are using another medicine. Your GP or pharmacist will ensure that the medication is right for you.
Reviewed by: Amie Anand
Published: February 2025
Next review: February 2028
Some medicines used to control conditions like type 1 and type 2 diabetes, such as insulin and metformin, can interact with Mounjaro. This is because these kinds of drugs lower your blood sugar.
Mounjaro can also lower your blood sugar.1 This means that taking it with a diabetes medication can be dangerous if not appropriately monitored by a health professional. It can lead to hypoglycaemia – a condition that causes extreme low blood sugars (below 4mmol/L).
If you are hypoglycaemic you might have:
- Shortness of breath
- Dizziness
- Blurred vision
- Heart palpitations
- Loss of consciousness.2
Hypoglycaemia can be managed by getting a sugary drink or snack immediately. After 15 minutes, if your blood sugar is not above 4 mmol/l, have a more substantial meal like a sandwich. This should help your blood sugar return to normal levels.
If someone you know has hypoglycaemia that cannot be treated with food or drink, put them in the recovery position and give them a glucagon injection if you know how. If you do not have a glucagon injection available and they have lost consciousness, call 999 immediately.2
Medicines like warfarin and digoxin can interact with tirzepatide, the active ingredient in Mounjaro. It can change how the medicine is absorbed. In some cases, you may need to find an alternative weight loss medicine, or your GP may monitor you closely while taking Mounjaro to make sure your heart health remains stable.1
If you are taking medications like somapacitan and somatrogon, your dose might be adjusted if you start to use Mounjaro. This is because these medicines can increase your blood sugar levels. Your GP may need to make sure that the effects of each medication are balanced.1
Do drugs and alcohol have an impact on Mounjaro?
If you take recreational drugs or drink more than 14 units of alcohol a week while using Mounjaro, you may put yourself at risk of hypoglycaemia. This is when your blood sugar falls to a dangerous level (below 4 mmol/l).
Alcohol can also cause a high blood sugar depending on how much you drink. If your blood sugar is too high, you may feel very thirsty, weak, tired and have blurred vision. To prevent high blood sugar, avoid alcohol as well as sugary and starchy foods. You should also try to manage stress and follow any advice given by your doctor.
No. It is not advised to take more than one weight loss medication at the same time unless it is specifically prescribed by your doctor. The active ingredients in weight loss medications have a similar effect on your body. So, using more than one at the same time could cause unwanted and potentially dangerous side effects.3
If you are not happy with the weight loss medicine you are on, you can discuss your options with your doctor or pharmacist.
Mounjaro can reduce the efficacy of different oral contraceptives. If you are taking Mounjaro and wanting to avoid pregnancy, make sure you are using condoms during sex for the entirety of your treatment. If you have questions about your contraception, or would like to change your method of contraception, discuss it with your GP. You should have this conversation before starting your medicated weight loss treatment.4
Some painkillers, like ibuprofen, may not be suitable to take with Mounjaro as they can increase your risk of bleeding or cause irritation in your stomach. If you choose to take Mounjaro, it is best to discuss your pain management options with your GP or pharmacists.5
What do I do if Mounjaro is not right for me?
If Mounjaro is not suitable for you, there are lots of weight loss approaches you can take – including the use of different medicated treatments. There are several safe options that you can try with the support and supervision of a healthcare professional.
- Tirzepatide | Interactions | BNF content published by NICE. Accessed January 20, 2025. https://bnf.nice.org.uk/interactions/tirzepatide/
- Low blood sugar (hypoglycaemia). nhs.uk. October 19, 2017. Accessed March 21, 2024. https://www.nhs.uk/conditions/low-blood-sugar-hypoglycaemia/https://www.nhs.uk/conditions/low-blood-sugar-hypoglycaemia/
- Drug Interaction Report: semaglutide, tirzepatide. Drugs.com. Accessed January 28, 2025. https://www.drugs.com/drug-interactions/semaglutide-with-tirzepatide-3878-0-4363-0.html
- Levonorgestrel and Mounjaro Interactions. Drugs.com. Accessed January 28, 2025. https://www.drugs.com/drug-interactions/levonorgestrel-with-mounjaro-1461-0-4363-20051.html
- Tirzepatide Injection. Cleveland Clinic. Accessed January 28, 2025. https://my.clevelandclinic.org/health/drugs/23789-tirzepatide-injection